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In 89% of the prospectively followed pregnancies, drug treatment was initiated prior to pregnancy and was discontinued at some point crestor in the first trimester when pregnancy was identified .
Rosuvastatin crosses the placenta in rats and rabbits and is found in fetal tissue crestor and amniotic fluid at 3% and 20%, respectively, of the maternal plasma concentration following a single 25 mg/kg oral gavage dose on gestation day 16 in rats .
A higher fetal tissue distribution (25% maternal side effects of generic crestor generic brand for crestor crestor 5mg tablets information can plasma concentration) was observed in rabbits after a single oral gavage dose of 1 mg/kg on gestation day 18 .
Rosuvastatin administration did not indicate a teratogenic effect in rats at ≤25 mg/kg/day or in rabbits ≤3 mg/kg/day (doses crestor reviews is crestor dangerous crestor and blood pressure side effects of crestor vs lipitor equivalent to the MRHD of 40 mg/day based on AUC and body surface area, respectively) .
In female crestor rats given 5, 15 and 50 mg/kg/day before mating and continuing through to gestation day 7 resulted in decreased fetal body weight (female pups) and delayed ossification at 50 mg/kg/day (10 times the human exposure at the MRHD dose of 40 mg/day based on AUC) .
In pregnant rats given 2, 10 and 50 mg/kg/day of rosuvastatin from gestation day 7 through lactation day 21 (weaning), decreased pup survival occurred at 50 mg/kg/day (dose equivalent to 12 times the crestor goes generic crestor generic when what happens if i stop taking crestor crestor at night MRHD of 40 mg/day based body surface area) .
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